tenOever Lab Atlas
A living organizational and strategic resource for the lab — projects, people, capabilities, and research themes in one place.
Three Connected Research Lanes
Mechanistic pathogenesis
Reveal how viral activities, cell states, and time windows drive sensing, inflammation, pathology, or protection.
Programmable immune instruction
Impose, withhold, or redirect immune signals through engineered viral genomes and RNA logic.
Respiratory delivery & therapy
Develop controllable respiratory delivery systems for airway-relevant payloads and therapeutic editing.
Projects
Immune Hierarchy
Leon Hsieh
Define how antigen acquisition, presentation context, and abundance shape the hierarchy of adaptive immunity.
ADAR1 Licensing
Morgane Baldaccini
Test whether vertebrate RNAi machinery provides the licensing context that permits productive ADAR1 editing.
IAV Fitness
Alvaro Fajardo
Resolve how early co-infection and segment completeness create positive selection and larger viral burst size.
IAV Kink-turn / Splicing
Raman Kaur
Use orthogonal RNA-binding logic to expose the viral and host requirements governing influenza splicing.
Influenza HA Antagonism of Membrane Signaling
Fiorella Chacon
Determine how influenza HA alters plasma-membrane organization and suppresses signaling initiated by extracellular ligands.
NS1 Multifunctionality
Abigail Korenek
Dissect separable NS1 functions and the cell-state consequences of selectively removing them.
AI-Designed IFN-β Mimetic
Abigail Korenek
Engineer a partially functional IFN-β mimetic that preserves broad antiviral activity while reducing the systemic inflammatory toxicity associated with therapeutic interferon.
Bone-Marrow Response to miRNA-Targeted IAV
Abigail Korenek
Define how miRNA-targeted influenza variants reshape bone-marrow transcription and myeloid output, with emphasis on the strong CD11b-associated phenotype observed with HANA.
IAV ORF-Targeting Library
Ryla Cantorgenali
Use miRNA-targeted silencing across influenza ORFs to assign segment-level effects on viral replication and host response.
miRNA Logic Gates
Ryla Cantorgenali
Use endogenous microRNA programs to make synthetic RNA systems sense and respond to cell identity.
LIN28 / let-7 ON-Gates
Sydney Pimentel
Build cell-selective positive logic that activates vector payloads only in the intended biological context.
Sendai Gene-Delivery Platform
Shared platform
Map and control respiratory-vector biodistribution, persistence, payload activity, and in vivo restriction.
DARPA CURES / HERMES
Shared program
Develop modular synthetic RNA vectors capable of transient delivery and durable therapeutic genome modification.
CAPTURE / CPIV3
Jonathan Dever
Expand the lab’s respiratory delivery toolkit through complementary vector architectures and deployment strategies.
Sendai R2 / PRINT
Sydney Pimentel
Advance programmable RNA delivery architectures that separate replication, payload, and targeting functions.
Universal Flu Vaccine
Leon Hsieh
Engineer a locally restricted influenza vaccine that builds broad, durable respiratory protection.
RESPOND PPG
No active project owner
Define how controlled viral perturbation engages lung-resident immunity across experimental and human lung systems.
Stem-cell Sensor Circuits
Ryla Cantorgenali
Couple endogenous differentiation signals to programmable RNA circuits that report or direct cell fate.
Long COVID
Lucia Carrau
Connect persistent post-infectious states to tractable mechanisms and respiratory model systems.
People
Ben tenOever
Principal investigator
Program direction and narrative architecture
Lucia Carrau
Assistant professor
Scientific continuity and cross-project experimental design
Maryline Panis
Lab manager
Operations, FACS, and institutional memory
Mark Chua
Senior scientist
Virology, reverse genetics, and vector quantification
Raman Kaur
Senior scientist
IAV splicing and high-precision pilots
Leon Hsieh
Postdoctoral fellow
Immune hierarchy and universal vaccine logic
Morgane Baldaccini
Postdoctoral fellow
ADAR1, RNAi, RISC, and RNA biology
Ryla Cantorgenali
Graduate student
IAV ORF targeting, miRNA gates, RNA circuits, and stem-cell sensors
Fiorella Chacon
Graduate student
HA signaling and single-cell interpretation
Sydney Pimentel
MD/PhD candidate
Sendai logic, R2/PRINT, and in vivo validation
Abigail Korenek
MD/PhD candidate
NS1 multifunctionality, IFN-β mimetics, and bone-marrow responses to miRNA-targeted influenza
Jonathan Dever
Research associate
DARPA support and CAPTURE/CPIV3 development
Cameron Mayer
Research coordinator
Animal colonies, compliance, and institutional cores
Molly Durawa
Animal technician
In vivo testing capacity
Hedy Rocha
Animal technician
In vivo testing capacity
Judy Minkoff
Scientific writer
Grants, writing, website, and special projects
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