LHS_INITIATIVE / TRACE

Scope

TRACE, Learning Health System work, surveillance, sampling, respiratory-virus monitoring, AMR surveillance, and health-system-facing translational implementation.

Current Architecture

TRACE is a two-arm Learning Health System pilot: - AMR surveillance centered on Staphylococcus aureus. - Viral surveillance focused on respiratory viruses.

Leadership

• Ben tenOever and Michael Phillips: co-directors.
• Bo Shopsin: AMR arm lead.
• Lucia Carrau: viral surveillance arm lead.
• Hank Wang / Clinical Microbiology: shared sample-processing dependency.
• Adriana Heguy / Genomics Core: PromethION sequencing resource.
• Alejandro Pironti and Gregory Putzel: AMR analytics/implementation contributors.

Key Distinction

TRACE should be presented as non-diagnostic surveillance that can use clinical sample streams or residual clinical material without replacing or duplicating the Clinical Microbiology Laboratory.

Infrastructure

• Clinical Microbiology.
• Sequencing capacity: PromethION; possible GridION and Illumina MiSeq i100 Plus considerations.
• Robotics such as Opentrons Flex.
• Epic/IT integration and hospital metadata.

Known Artifacts

• NYU_Microbiology_Strategic_Planning.pdf.
• TRACE_ProgramOverview.pptx.
• MCIT-TRACE-JUNE16.pptx.
• MCIT-TRACE.pptx.
• TRACE_IT_leadership_discussion.pptx.
• MCIT-TRACE.pdf.
• TRACE org-chart iterations and executive architecture visuals.

TODO

• Add final org chart, sample-selection workflow, data pipeline, Epic fields, IRB/operations status, and exact sequencing criteria.