Vector Registry
The Vector Registry is the canonical index of viral systems and construct families used by the lab.
Registry Fields To Use
Each vector page should eventually include:
- backbone;
- construct name and aliases;
- payload or modified ORF;
- miRNA target design, if applicable;
- rescue/manufacturing status;
- titering method;
- validated tropism;
- payload capacity;
- immunogenicity notes;
- in vivo dosing conventions;
- known failure modes;
- linked datasets;
- responsible people;
- biosafety/compliance notes.
Current Vector Families
| Vector family | Atlas page | Major use |
|---|---|---|
| Influenza reverse genetics | Influenza Reverse Genetics | Pathogenesis, immune hierarchy, antigen control, viral fitness. |
| HANA / PAM / PANA influenza constructs | IMMUNE HIERARCHY | miRNA-silenced constructs for antibody and CD8 immune profiling. |
| Recombinant Sendai virus | Sendai rSeV | Respiratory delivery, HERMES, miRNA logic, payload deployment. |
| BiSeV / deleted Sendai architectures | BiSeV | Delivery platform exploration and payload accommodation. |
| CPIB3 | CPIB3 | CAPTURE and next-generation respiratory vector development. |
| R2/PRINT | R2 PRINT | Payload/integration-related platform efforts. |
| miRNA gates | Vector Engineering, miRNA Gates | Cell-type restriction and payload/viral program logic. |
Immediate Curation Need
The vector pages are currently thinner than their scientific importance. v0.6 should prioritize construct architecture, validation status, and dataset links.