LONG_COVID

Scope

Long COVID / NeuroPASC, olfactory-system injury models, post-viral tissue dysfunction, manuscripts, and R01 strategy.

Working Model

Transient SARS-CoV-2 infection of the olfactory epithelium, especially sustentacular cells, produces selective olfactory sensory neuron injury and delayed/persistent neuroimmune response in the olfactory bulb without requiring productive brain infection.

Key Data Classes

• Golden hamster SARS-CoV-2 olfactory epithelium/olfactory bulb time course.
• Olfactory sensory neuron injury.
• Olfactory bulb microglial activation after viral clearance.
• cFos/immediate-early gene downregulation.
• Olfactory bulb inflammation persisting to approximately 30 dpi.
• Human olfactory bulb proteomics supporting interferon signaling.

Outputs / Grants

• LongCOVID_R01 and manuscript-style mechanistic narrative.
• Working title remembered: “Testing Olfactory Neuron Death as a Driver of Microglial Activation in PASC.”

TODO

• Add exact datasets, raw paths, figure files, cohort details, sample sizes, and analysis pipelines.