Capability Map

This page separates what the lab can do from what the lab has discovered. Capabilities are durable infrastructure; discoveries are scientific claims.

Viral Engineering

• Influenza reverse genetics.
• Recombinant Sendai virus engineering.
• BiSeV/deleted Sendai architectures.
• CPIB3/CAPTURE respiratory vector development.
• R2/PRINT-related payload systems.
• miRNA target insertion and cell-type restriction.
• miRNA ON-gate and related logic-layer designs.

Immune Perturbation

• Engineered viral programs that alter antigen expression, replication competence, and immune activation.
• Abortive or replication-defective viral systems that reshape antigen acquisition and immune engagement.
• Programmable manipulation of antibody and CD8 T-cell outcomes.

Delivery and Therapeutic Platform Work

• Respiratory delivery of large or complex payloads.
• Editor delivery concepts, including base and prime editing payloads.
• Biodistribution, tropism, immunogenicity, and payload-activity benchmarking.

Analysis and Measurement

• Single-cell and immune profiling.
• CD8 sequencing and TCR repertoire analysis.
• RNAfold/ADAR structure analysis.
• Deep mutational scanning.
• Long-read splicing analysis.
• In vivo respiratory challenge models.
• FACS sorting and downstream assay infrastructure.

Management Use

This map should be used for:

• onboarding;
• grant capability sections;
• collaboration intake;
• manuscript methods planning;
• identifying bottleneck expertise;
• deciding whether a project requires new infrastructure or can reuse an existing capability.