Negative Results and Abandoned Ideas

This page is intentionally preserved as institutional memory. Negative results are scientific assets when they prevent repeated dead ends or clarify why the lab changed direction.

Current Entries

ADAR1 licensing — superseded simple structure model

Earlier models in ADAR LICENSING considered simple local RNA structure, bowtie motifs, or Drosha-as-ADAR-competitor explanations. The current reconstruction treats these as superseded or rejected relative to a broader AGO2/RISC and DROSHA-associated licensing model.

Immune hierarchy — antigen-level model is incomplete

In IMMUNE HIERARCHY, HA surface depletion provides a straightforward explanation for reduced HA antibody quality and levels. The CD8 story is not explained as cleanly by direct targeting of dominant antigens. PA targeting does not appear to produce the expected dominant CD8 shift; the constructs look more similar than different, with major differences relating more to NP. This supports a broader antigen-capture-context model.

Future Entries To Add

• Failed vector-rescue designs.
• Payloads that were too large, unstable, toxic, or poorly expressed.
• miRNA designs that failed due to ADAR editing or other escape routes.
• In vivo dosing or delivery conditions that produced uninterpretable or negative data.
• Manuscript narrative paths that were abandoned and why.