DARPA CURES / HERMES

Purpose

DARPA-facing vector-delivery program centered on Sendai-virus-based delivery of therapeutic payloads, including editing systems.

Scientific Content

• rSeV and BiSeV vector architectures.
• Prime editing and base editing.
• Comparison of full-length deleted rSeV versus BiSeV.
• Potential target systems remembered in source summaries include Pcsk9 and reporter systems such as TIGER/tdTomato/mCherry contexts.
• miRNA gating and payload-cell specificity are addendum/extension areas.

People

• Ben tenOever
• Sydney Pimentel
• Jonathan Dever
• Raman Kaur
• Molly Durawa
• Hedy Rocha

Known Artifacts

• HERMES_CURES_Feb2026_v2.pdf
• HERMES_CURES_Jan2026_v2.pdf
• HERMES_Phase_II_Prime_Editing_SOW_Updated.docx

Caveat

Only remembered summaries and filename-level records are available here; verify against original DARPA documents before reporting.