RESPOND_PPG

Full Name

RESPOND: Respiratory Exposure and Sequelae: Pathogenesis, Outcomes, and Novel Determinants.

Scope

NHLBI P01/Program Project strategy integrating respiratory infection biology, spatial lung biology, human and mouse lung models, and immune mechanisms of pathogenesis and sequelae.

Mature Component Set

• Overall.
• Administrative Core.
• Spatial Lung Biology Core.
• Project 1 Khanna.
• Project 2 Nellore.
• Project 3 tenOever.

Leadership / People

• Ben tenOever: Contact PD/PI in remembered record.
• Kamal Khanna: MPI.
• Anoma Nellore: Project Lead, not MPI.

Current Strategic State

Pursue A1/resubmission only if response is substantive: - Repair Project 2 human-subjects protections. - Make P01 integration concrete and recurring. - Tighten Project 3 rigor/reviewer confidence. - Present Spatial Lung Biology Core as essential and integrated.

Known Files

• 5146751_Egrant.pdf
• 1P01HL184950-02.pdf
• Multiple component documents including Overall, Admin, Project, Core, biosketch, references, research strategy, specific aims.

TODO

• Add component-by-component ownership, summary-statement critique, revised aims, and resubmission calendar.